Nerve Growth Factor and Fibroblast Growth Factor Prevents Acute Qa-excitotoxicity in Rat Basal Forebrain
نویسندگان
چکیده
Adult Wistar rats were treated with unilateral intrastriatal injection of quinolinic acid (QA) in one single dose of 150 nM/L. The other two group of animals were pretreated with nerve growth factor (NGF) and fibroblast growth factor (FGF), respectively. Control group was treated with 0.154 mmol/L saline solution likewise. Activity of cytochrome c oxidase (COX) was decreased in the basal forebrain of neurotrophins (NTF)-treated animals. Striatal lesions led to the loss of tonic inhibitory inputs to the globus pallidus with consequent increase changes due to transsynaptic degeneration in the basal forebrain, will be also less extensive in the NTF-treated animals.
منابع مشابه
Udk 619:616.831-003.8 Nerve Growth Factor Protects Cholinergic Neurons against Quinolinic Acid-induced Excitotoxicity in Wistar Rats
The etiology of neuronal death in neurodegenerative diseases, including Huntington's disease (HD) is still unknown. There could be a complex interplay between altered energy metabolism, excitotoxicity and oxidative stress. Excitotoxic striatal lesions induced by quinolinic acid (QA), were used to test for the neuroprotective actions of nerve growth factor (NGF) on striatal cholinergic and GABAe...
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